Hair · Conditioning & Smoothing

Protein & Keratin Hair Treatment

How this page was made
This page was written with AI assistance and reviewed against the sources listed under References below. It is general information only, not medical advice. See our full disclaimer for how SHEA creates and reviews treatment information.
01

What it is

Hair fibers are made largely of keratin proteins. Bleaching, chemical processing, heat, ultraviolet exposure and everyday wear can alter the cuticle and internal structure of the hair shaft, contributing to roughness, porosity and breakage.

Protein treatments are conditioning treatments containing proteins, hydrolyzed proteins, peptides or amino acids. Depending on their molecular size and formulation, these ingredients may deposit on the hair surface or penetrate to some degree into damaged hair. Their effects are cosmetic and physical, rather than biological repair of a living structure.

Keratin smoothing treatments are a different category. They are salon services designed primarily to reduce frizz, alter curl or make hair easier to straighten and style. A smoothing solution is applied to the hair and is commonly followed by heat treatment with a blow dryer and flat iron.

Despite the shared word "keratin," a protein-conditioning treatment and a keratin smoothing service should not be assumed to work in the same way.

Ask what smoothing product is being used
Some hair-smoothing products contain formaldehyde, formalin or methylene glycol and can release formaldehyde gas when heated. Formaldehyde exposure can irritate the eyes, nose, throat, lungs and skin, and formaldehyde is classified as a human carcinogen. Not every smoothing product contains these ingredients, so the specific product and ingredient information matter.

02

Why people consider it

  • Hair that has become rough, porous or prone to breakage after bleaching or other chemical processing
  • Wanting temporary conditioning or improvement in the feel and manageability of damaged hair
  • Frizz or curl that someone wants to reduce with a smoothing treatment
  • Wanting hair that is temporarily easier to straighten or style

03

What the experience is like

Protein treatment: a protein-containing conditioning product is applied to the hair. Depending on the formulation, it may be left on for a period of time, used with heat, rinsed out or incorporated into another conditioning service.

Keratin smoothing: a smoothing formulation is applied through the hair and is commonly followed by blow-drying and flat-ironing. Heating is an important safety consideration because some smoothing products can release formaldehyde gas during this stage.

Application time, heat settings, washing instructions and how long the result lasts depend on the particular product and protocol. Follow the instructions for the specific formulation rather than assuming that all protein or keratin treatments require the same aftercare.


04

Limitations & considerations

  • Protein treatments do not permanently reconstruct damaged hair. Hair fibers are non-living structures, and cosmetic products can modify their surface or physical properties without restoring them to an undamaged biological state
  • The behavior of hydrolyzed proteins depends partly on molecular size and formulation. Evidence for one hydrolyzed keratin preparation should not automatically be transferred to every protein treatment
  • Laboratory studies showing changes in penetration, stiffness or breakage of treated hair fibers do not establish how much visible benefit a particular salon treatment will provide
  • Keratin smoothing is primarily a smoothing and manageability service. It should not be confused with a treatment for hair loss, scalp disease or follicle function
  • Some smoothing products can release formaldehyde when heated. Exposure can affect both the person receiving the service and salon workers, particularly when ventilation is inadequate
  • Labels such as "keratin," "Brazilian," "protein," or "formaldehyde-free" do not by themselves describe the complete chemistry or safety profile of a smoothing product. Ask for the product name and ingredient or safety information when available
  • Repeated chemical processing and high-temperature styling can themselves affect the hair shaft, so the condition of the hair and the specific procedure matter when considering another treatment
  • Results and longevity vary by formulation, hair condition, washing, styling and other hair-care practices
Evidence note
Laboratory research supports the idea that some hydrolyzed keratin peptides can interact with damaged hair fibers. Malinauskyte and colleagues tested hydrolyzed keratins of different molecular weights on chemically relaxed textured hair. Lower- and mid-molecular-weight compounds penetrated into the hair cortex, while the high-molecular-weight keratin primarily deposited on the hair surface. Some preparations also changed mechanical measurements and reduced breakage under the laboratory conditions studied.
This research is useful for understanding how hydrolyzed proteins can behave on damaged hair, but it does not establish the effectiveness or duration of a particular commercial salon protein treatment. Product formulation, concentration, molecular size and application conditions can differ substantially.
Hair smoothing has a separate safety issue. The U.S. Food and Drug Administration states that some hair-smoothing products contain formaldehyde, formalin or methylene glycol and release formaldehyde gas when heated. Exposure can cause eye, respiratory and skin irritation, and formaldehyde is classified as a human carcinogen. The FDA recommends checking the ingredient information and asking the salon about the specific product being used.
South Korea's Ministry of Food and Drug Safety maintains current cosmetic safety standards governing prohibited and restricted cosmetic ingredients. Because product composition and regulatory requirements can change, the safety of a smoothing treatment should be considered using the actual product being applied rather than the general label "keratin treatment."

References

Laboratory research and regulatory information relevant to hydrolyzed keratin and hair-smoothing products.

1. Malinauskyte E, Shrestha R, Cornwell PA, Gourion-Arsiquaud S, Hindley M. Penetration of different molecular weight hydrolysed keratins into hair fibres and their effects on the physical properties of textured hair. International Journal of Cosmetic Science. 2021;43(1):26–37.
Peer-reviewed · Laboratory hair-fiber study · Hydrolyzed keratin
2. U.S. Food and Drug Administration. Hair Smoothing Products That Release Formaldehyde When Heated.
Regulatory safety information · Formaldehyde · Hair smoothing
3. South Korea Ministry of Food and Drug Safety. Regulations on the Safety Standards for Cosmetics.
Current regulatory standard · MFDS · South Korea
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